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It is commonly Energetic in the 10–20 mg vary, taken orally or nasally and extremely dose-delicate. Insufflating (snorting) needs a A lot lessen dose, typically not exceeding 10 mg, but this method of use elicits a very painful sensation inside the nasal cavity for 10 minutes or so. Shulgin categorized 2C-E as being a member on the "Magical Fifty